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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are often described by their focus on practical aspects of design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.

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Mobile compatibility

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Legality

Pragmatic Play is known for its top-notch games, and for providing a superior user experience. The software is available on mobile devices and in a variety of languages. It has been recognized as one of the leading casino gaming platforms despite its relative youth. Wolves is one of the most recent releases which is a five-reel slot machine that has a high RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be a great way to identify the cause-effect relationship between an intervention and its outcomes. They should not, however, be used to replace explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic trial which includes recruitment, design and delivery of the intervention, and monitoring.

There is a positive increase in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to remember, however, that the majority of these studies were conducted in primary care settings.